Definition of Nano Liquid Chromatography
Posted in Nano HPLC on Jun 18, 2007
It is interesting to note that 20 years later there is still no clear definition of nano-LC. Due to a relatively large size of the columns used in nano-HPLC (10-140 μm), the method does not fall within the realm of the conventional definition of nanotechnology – “the control of matter on a scale smaller than 1 micrometre”.
However, most researches subscribe to the view expressed in the article “Instrumental Requirements for Nanoscale Liquid Chromatography” (DOI: 10.1021/ac9508964). The authors suggested the definition based on the flow rate range rather than the inner diameter of the tubing or its material. They proposed that the liquid chromatography method that uses packed microcolumns with 10-150 μm ID and flow rates of 10-1000 nL/min to be classified as nano-LC.
[table "3" seems to be empty /]4 Responses to “Definition of Nano Liquid Chromatography”
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i have performed HPLC MS and in my results i can see a parameter called NL
does any one know what that is ?
can i use this as the concentration of my target compound?
If we are using a guard column only for analysis on HPLC system so can we count it as nano lc?
Nikhil,
Though I appreciate your interest in my blog, I don’t really run a q&a service here.
Yes, sometimes people do ask questions and if I like them, I research and answer them.
You can easily find info about a chemical compound yourself, just by searching in Google, ChemSpider (http://www.chemspider.com/), ChemFinder (http://chemfinder.cambridgesoft.com/) and many other sites.
Here is a nice link about the drug you are interested in:
http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=3946
I want the total information about compound named as”Cefotaxime Sodium”.
Thanks Sir.
Can you send this as early as possible.